Hercules was married to Deianeira. Long after their marriage, one day the centaur Nessus offered to ferry them across a wide river that they had to cross. Nessus set off with Deianeira first, but tried to abduct her. When Hercules realized the centaur's real intention, Hercules chased after him and shot him with an arrow which was poisoned with Hydra's blood. Before he died, Nessus told Deianeira to take some of his blood and treasure it, since it was a very powerful medicine and: if she ever thought Hercules was being unfaithful, the centaur told her, the blood would restore his love. Deianeira kept the vial of blood.
Many years after that incident she heard rumours that Hercules had fallen in love with another woman. She smeared some of the blood on a robe and sent it to Hercules by a servant named Lichas. Lichas spilled some blood on the floor and when the sun's rays fell on it the blood begun to burn. Because of this Deianeira began to suspect Nessus's advice and decided to send another servant to fetch Lichas back before he could hand over the blood soaked robe to Hercules. She was too late. Hercules had already put on the robe and when he did so the blood still poisoned from the same arrow used by Hercules, burnt into his flesh. When he jumped into a nearby river in hope of extinguishing the fire, it only made it worse. When he tried to rip off the robe from his body his organs were also ripped with him.
Furiously, Hercules caught Lichas and tossed him into the sea. After that he told his friend Philoctetes to build him a pyre on the mountain Oata. He was burnt to death on the pyre. Before dying, Hercules offered his bow and arrows as a token of gratitude to Philoctetes. His father Zeus then turned him into a god. Deianeira, after hearing what she had caused, committed suicide.